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普萘洛尔化学名为1-异丙氨基-3-(1-萘氧基)-2-丙醇盐酸盐,临床上常称为心得安。口服后吸收较完全,但进入全身循环前大部分在肝脏被代谢,生物利用度为30%,半衰期为2~3 h,经肾脏排泄。普萘洛尔能竞争性地阻滞β受体,大剂量时可抑制钠离子内流,有稳定细胞膜作用。常用于治疗心律失常、心绞痛、高血压及肥厚型心肌病等。婴幼儿血管瘤(infantile hemangiomas,IH)是婴幼儿常见的良性肿瘤[1],属于错构瘤性质,具有畸形和肿瘤的双重特点。IH由高有丝分裂率的内皮细胞和间质成分组成,总发生率为1%~12%,
Propranolol chemical name is 1-isopropylamino-3- (1 - naphthyloxy) -2-propanol hydrochloride, clinically known as propranolol. After oral absorption more complete, but most of the systemic circulation into the liver before being metabolized, bioavailability of 30%, half-life of 2 ~ 3 h, excreted by the kidneys. Propranolol can competitively block the beta receptor, high-dose sodium ions can inhibit influx, a stable cell membrane. Commonly used in the treatment of arrhythmia, angina, hypertension and hypertrophic cardiomyopathy. Infantile hemangiomas (IH) is a common benign tumor in infants and young children [1], which belongs to the hamartomatous nature and has the double features of deformity and tumor. IH is composed of hypermetastatic endothelial cells and interstitial components with a total incidence of 1% to 12%