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目的了解肥胖与非肥胖原发性醛固酮增多症(原醛)患者临床特征的差异。方法回顾性分析2006年2月至2011年2月,就诊于新疆维吾尔自治区人民医院高血压诊疗中心的原醛患者633例,以体质量指数28kg/m2为分割点,分为肥胖组246例和非肥胖组387例,比较两组患者临床生化指标、合并症等情况。结果两组患者年龄、病程、基础血压水平、坐位肾素、坐位醛固酮、空腹及餐后2h血糖、低密度脂蛋白胆固醇、尿钾和室间隔厚度差异无统计学意义(均P>0.05)。肥胖组腹围[(104.5±8.4)比(90.3±8.6)cm]、空腹胰岛素[(14.7±9.8)比(11.1±8.9)μmol/L]及餐后3h胰岛素水平[(37.3±29.5)比(26.5±30.2)μmol/L]、血钾[(3.77±0.37)比(3.66±0.41)mmol/L]明显高于非肥胖组(均P<0.05)。肥胖组合并睡眠呼吸暂停综合征及脂肪肝的发生率明显高于非肥胖组(均P<0.05)。结论肥胖的原醛患者更易合并糖脂代谢紊乱、睡眠呼吸暂停综合征及脂肪肝。
Objective To understand the clinical characteristics of obese and non-obese patients with primary aldosteronism (primary aldehyde). Methods A retrospective analysis of 633 cases of primary aldosteronism patients who visited the Hypertension Treatment Center of People’s Hospital of Xinjiang Uyghur Autonomous Region from February 2006 to February 2011 was divided into obesity group (246 cases) and body mass index (28kg / m2) 387 cases of non-obesity group, comparing two groups of patients clinical and biochemical indicators, complications and so on. Results There were no significant differences in age, course of disease, basal blood pressure, sitting renin, sitting aldosterone, fasting and 2h postprandial blood glucose, LDL cholesterol, urinary potassium and interventricular septum thickness in both groups (all P> 0.05). (104.5 ± 8.4) vs (90.3 ± 8.6) cm], fasting insulin [(14.7 ± 9.8) vs (11.1 ± 8.9) μmol / L] and postprandial 3h insulin level [(37.3 ± 29.5) (26.5 ± 30.2) μmol / L] and potassium (3.77 ± 0.37) vs (3.66 ± 0.41) mmol / L, respectively. The incidence of obesity combined with sleep apnea syndrome and fatty liver was significantly higher than that of non-obese patients (all P <0.05). Conclusion Obesity patients with primary aldosteronism are more likely to be associated with dyslipidemia, sleep apnea syndrome and fatty liver.