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目的评价卡维地洛联合螺内酯治疗难治性高血压的有效性与心动图改变。方法选择难治性高血压患者64例,随机平分为两组,监测用药期间血压改变情况、临床疗效与超声心动图改变发生情况。结果治疗组采用卡维地洛及螺内酯联合治疗(治疗组)的有效率为96.88%,而采用传统治疗方法(对照组)的有效率为56.25%,治疗组优于对照组(P<0.05);经过治疗后,两组患者的舒张压(DBP)和收缩压(SBP)都有明显下降,且治疗组患者的血压下降更为明显(P<0.05);治疗组患者室间隔、左室后壁厚度均显著下降(P<0.05)。结论卡维地洛联合螺内酯治疗难治性高血压有效,多普勒检查有助于检出患者的早期LA损害,并评估其损害的严重程度。
Objective To evaluate the efficacy and cardiogram changes of carvedilol combined with spironolactone in the treatment of refractory hypertension. Methods Sixty-four patients with refractory hypertension were randomly divided into two groups. The changes of blood pressure, clinical efficacy and echocardiographic changes were monitored during the treatment. Results The effective rate of the treatment group was 96.88% with the combined treatment of carvedilol and spironolactone, while the effective rate was 56.25% in the traditional treatment group (control group), and the treatment group was superior to the control group (P0.05) (DBP) and systolic blood pressure (SBP) decreased significantly in both groups after treatment, and the blood pressure in the treatment group decreased more significantly (P <0.05). After treatment, the interventricular septum, left ventricular Wall thickness decreased significantly (P <0.05). Conclusion Carvedilol combined with spironolactone is effective in treating refractory hypertension. Doppler examination can help detect the early LA lesion in patients and assess the severity of the damage.