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目的探讨不稳定型心绞痛患者应用阿托伐他汀治疗对血脂及血清炎症因子C-反应蛋白的影响。方法如皋市人民医院2009年8月至2011年6月收治的不稳定型心绞痛患者80例随机分为观察组和对照组各40例,对照组给予不稳定型心绞痛的常规治疗,如硝酸酯类、β-受体阻滞剂、血管紧张素转换酶抑制剂及抗凝等治疗。治疗组在常规治疗的基础上加用阿托伐他汀治疗,20mg/d,口服,连用8周。测定两组治疗前后血清中hs-CRP和总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果两组患者在入院时炎症因子hs-CRP及TC、TG、HDL-C、LDL-C水平比较差异无统计学意义(P>0.05),在治疗4周、8周后hs-CRP及TC、TG、LDL-C两组均呈下降趋势,但治疗组下降优于对照组,两组比较差异有统计学意义(P<0.05)。结论阿托伐他汀治疗不稳定型心绞痛不但能降低血脂还可减轻其炎症反应,有利于动脉粥样硬化斑块的稳定,对UAP的发生、发展及预后有重要作用。
Objective To investigate the effects of atorvastatin on serum lipids and serum inflammatory cytokine C-reactive protein in patients with unstable angina pectoris. Methods 80 patients with unstable angina pectoris admitted from August 2009 to June 2011 in Rugao People’s Hospital were randomly divided into observation group and control group, 40 cases in each group. The control group was given routine treatment of unstable angina, such as nitrates , Β-blockers, angiotensin-converting enzyme inhibitors and anticoagulant therapy. The treatment group was treated with atorvastatin on the basis of routine treatment, 20mg / d orally for 8 weeks. Serum hs-CRP, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured before and after treatment. Results There was no significant difference in the levels of hs-CRP, TC, TG, HDL-C and LDL-C between the two groups at admission (P> 0.05) , TG, LDL-C decreased in both groups, but the treatment group decreased better than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusions Atorvastatin treatment of unstable angina pectoris can not only reduce the blood fat but also reduce the inflammatory reaction, is conducive to the stability of atherosclerotic plaques, and plays an important role in the occurrence, development and prognosis of UAP.