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目的:探讨保留睾丸动脉显微手术联合服用麒麟丸治疗双侧精索静脉曲张(VC)合并少弱精子症的临床疗效。方法:60例双侧精索静脉曲张并少弱精子症患者,随机分为两组,单纯手术组30例,显微手术联合服用麒麟丸组30例,疗程12周,每次服用6 g,每日3次,观察治疗后第4、8、12周两组患者精子浓度、精液量、精子活力(a+b级)、畸形精子百分率、血清Inh B、LH、TT和FSH水平变化,并计算睾酮分泌指数(TSI=TT/LH)。结果:患者均手术成功,术后症状消失,精子浓度、精液量、精子活力明显提高,畸形精子百分率明显降低,术后血清Inh B、TT、TSI明显改善,FSH、LH含量降低,与术前比较,差异有统计学意义(P﹤0.01)。手术联合服用麒麟丸组治疗12周后血清Inh B、LH、TT及TSI分别为(138.96±22.26)ng/L、(3.17±0.12)IU/L、(13.98±3.02)nmol/L、(4.41±0.53)nmol/IU,单纯手术组治疗12周后分别为(129.54±22.23)ng/L、(3.59±0.11)IU/L、(12.68±3.12)nmol/L、(3.53±0.51)nmol/IU,两组间对比差异有显著性(P﹤0.05)。手术联合服用麒麟丸组受孕22例,受孕率为73.4%,比单纯手术组受孕11例、受孕率为36.6%效果显著(P﹤0.05)。结论:保留睾丸动脉显微手术联合服用麒麟丸治疗双侧精索静脉曲张所致少弱精子症,对于术后精液质量改善明显、疗效满意。
Objective: To investigate the clinical effect of preserving the testicular artery microsurgery combined with Kirin Pills in the treatment of bilateral varicocele (VC) combined with oligo-asthenospermia. Methods: Sixty patients with bilateral varicocele and oligoasthenospermia were randomly divided into two groups. Thirty patients in the simple operation group and 30 patients in the unicinged group were treated with microsurgery for 12 weeks. Each time they took 6 g, The changes of sperm concentration, sperm volume, sperm motility (a + b), percentage of abnormal sperm, serum Inh B, LH, TT and FSH levels were observed in the two groups at 4, 8 and 12 weeks after treatment Calculate the testosterone secretion index (TSI = TT / LH). Results: The operation was successful and the symptoms disappeared. The sperm concentration, sperm volume and sperm motility were significantly increased. The percentage of deformity sperm was significantly decreased. The serum levels of Inh B, TT and TSI were significantly improved, while the levels of FSH and LH were decreased. The difference was statistically significant (P <0.01). The serum levels of Inh B, LH, TT and TSI were (138.96 ± 22.26) ng / L, (3.17 ± 0.12) IU / L and (13.98 ± 3.02) nmol / L respectively after taking Kirin Pills for 12 weeks ± 12.53) nmol / IU, respectively, and were (129.54 ± 22.23) ng / L, (3.59 ± 0.11) IU / L and (12.68 ± 3.12) nmol / L and (3.53 ± 0.51) nmol / IU, the difference between the two groups was significant (P <0.05). Twenty-two cases were conceptioned with unicorn bolus. The pregnancy rate was 73.4%. Compared with the operation group, 11 cases were conceptioned and the pregnancy rate was 36.6% (P <0.05). CONCLUSIONS: Testicular arterial microsurgery combined with unicorn pills in treatment of oligozoospermia caused by bilateral varicocele has obvious effect on postoperative sperm quality, and the curative effect is satisfactory.