论文部分内容阅读
【目的】探讨细胞黏附分子CD44变异型外显子‐6（CD44‐v6）、整合素β1与根治性胰腺癌患者预后的关系。【方法】对在本院接受治疗的85例胰腺癌患者，比较CD44‐v6、整合素β1在不同临床病理特征的胰腺癌组织中的阳性表达率及其与肿瘤标志物癌胚抗原（CEA）、糖类抗原19‐9（CA19‐9）糖类抗原125（CA125）水平的相关性。【结果】死亡组患者CD44‐v6、整合素β1阳性表达率和CEA、CA19‐9，CA125水平明显高于生存组，且差异具有显著性（ P ＜00．5）；年龄较大、分化程度低、有远处转移、侵犯血管的胰腺癌患者CD44‐v6和整合素β1阳性表达率较高（ P ＜00．5），而不同性别、肿瘤直径和是否有淋巴结侵犯的患者术后CD44‐v6，整合素β1阳性表达率无明显差异（ P ＞0．05）；胰腺癌患者 CD44‐v6、整合素β1阳性表达率与 CA19‐9、CA125、CEA呈显著正相关（ P ＜00．5）。【结论】CD44‐v6、整合素β1在预后较差的胰腺癌患者中高表达，且与肿瘤标志物水平正相关，可作为判断患者预后的重要指标。“,”[Objective]To investigate the relationships between cell adhesion molecule CD44 variant exon‐6 (CD44‐v6) and integrin beta 1 with the prognosis of surgical patients with pancreatic cancer .[Methods]Eight‐y‐five patients with pancreatic cancer who received treatment in our hospital were chosen as the study subjects . The positive expression rates of CD44‐v6 and integrin beta‐1 in the pancreatic cancer tissues of the patients with different clinical‐pathological features were deterimined .The correlation between the positive expression rates of CD44‐v6 ,integrin beta 1 and the levels of tumor markers (CEA ,CA19‐9 and CA125) was analyzed .[Results]The positive expression rates of CD44‐v6 ,integrin beta 1 ,antigen (CEA) ,carbohydrate antigen 19‐9 (CA19‐9) ,and carbohydrate antigen 125 (CA125) in the death group were significantly higher than those in the survival group ,the difference was statistically significant ( P <0 0.5) .Pancreatic cancer patients with old age ,lower differentiation ,distant metastasis ,and invasion of vascular showed higher positive expression rates in CD44‐v6 and integrin beta‐1 ,the differences were statistical significance ( P <0 0.5) .There were no signif‐icant differences showing the expression rates of CD44‐v6 and integrin beta 1 with patient gender ,tumor size , and local lymph node invasion ( P <0 0.5) . .The positive expression rate of CD44‐v6 and integrin beta‐1 in pancreatic cancer patients were significantly positively correlated with CA19‐9 ,CA125 and CEA ,and the difference was statistically significant ( P <0 0.5) .[Conclusion]The high expression of CD44‐v6 and integrin beta‐1 contributes to the poor prognosis in patients with pancreatic cancer ,and is associated with tumor mark‐ers (CEA ,CA19‐9 and CA125) .It can be used as an important indicator of the prognosis as well .