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目的观察弥散性毒性甲状腺肿(GD)儿童在疾病不同阶段血清IL-10、12水平变化的临床意义。方法采用酶联免疫吸附法(ELISA)测定GD患儿疾病不同阶段(新发病、治疗未缓解、治疗缓解3个阶段)血清IL-10、12水平。检测游离T3、T4(FT3、FT4),敏感TSH(sTSH),甲状腺微粒体抗体(TMAb)、甲状腺球蛋白抗体(TGAb)、甲状腺受体抗体(TRAb)、甲状腺刺激抗体(TSI)水平并分析其间的关系。结果IL-10、12在GD新发病组均显著高于未缓解组、缓解组和健康对照组(Pa<0.05)。IL-12与sTSH呈显著负相关(r=-0.309 P<0.05),IL-10与FT4、FT3呈显著正相关(r=0.350,0.334 Pa<0.05)。结论IL-10、12均参与GD的发病,可作为病情监测的指标。
Objective To investigate the clinical significance of serum levels of IL-10,12 in children with diffuse toxic goiter (GD) at different stages of the disease. Methods Serum levels of IL-10 and 12 were measured in different stages of GD children’s disease (new onset, non-remission and remission of treatment) by enzyme-linked immunosorbent assay (ELISA). The levels of free T3, T4 (FT3, FT4), sensitive TSH (sTSH), thyroid microsomal antibody (TMAb), thyroglobulin antibody (TGAb), thyroid receptor antibody (TRAb) and thyroid stimulating antibody (TSI) The relationship between. Results IL-10,12 in the newly diagnosed GD group was significantly higher than that in the non-remission group, remission group and healthy control group (Pa <0.05). There was a significant negative correlation between IL-12 and sTSH (r = -0.309 P <0.05). There was a significant positive correlation between IL-10 and FT4 and FT3 (r = 0.350,0.334 Pa <0.05). Conclusion Both IL-10 and 12 are involved in the pathogenesis of GD and can be used as indicators of disease surveillance.