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为探讨煤工尘肺发生早期的自由基代谢变化，系统测定５４ 例Ⅰ期煤工尘肺患者，５９ 例 Ｘ 线表现尚不足以诊断为Ⅰ期尘肺的０ ＋ 人群及４０ 例健康对照者血液中的过氧化脂质（ Ｌ Ｐ Ｏ） 、唾液酸（ Ｓ Ａ） 、谷胱甘肽（ Ｇ Ｓ Ｈ） 、维生素 Ａ（ Ｖ Ａ） 、维生素 Ｅ（ Ｖ Ｅ） 含量及超氧化物歧化酶（ Ｓ Ｏ Ｄ） 、谷胱甘肽过氧化物酶（ Ｇ Ｓ Ｈ Ｐｘ） 和过氧化氢酶（ Ｃ Ａ Ｔ） 活力。结果显示，０ ＋ 组人群及Ⅰ期煤工尘肺患者体内 Ｌ Ｐ Ｏ 及 Ｓ Ａ 水平均明显高于对照组，而 Ｇ Ｓ Ｈ Ｐｘ ， Ｃ Ａ Ｔ 活力及 Ｖ Ａ、 Ｖ Ｅ 含量则较对照组明显降低， Ｓ Ｏ Ｄ则呈代偿性增加。表明自由基代谢紊乱及氧化／ 抗氧化状态失衡的变化早于煤工尘肺诊断的 Ｘ 线影像学改变。
In order to explore the change of free radical metabolism during the early stage of coal worker’s pneumoconiosis, 54 cases of stageⅠ coal worker’s pneumoconiosis were systematically studied. Fifty-nine patients with 0 + population who were not yet diagnosed as stage Ⅰ pneumoconiosis and 40 healthy controls L P O, S A, G S H, V A, V E and superoxide dismutase D), glutathione peroxidase (G S H Px) and catalase (C A T) activity. The results showed that the levels of L P O and S A in patients with 0 + group and patients with stage Ⅰ coal worker’s pneumoconiosis were significantly higher than those in the control group, while the activities of G S H-Px, C A T and the contents of V A and V E were significantly Group significantly reduced, S O D was compensatory increase. Show that free radical metabolism disorders and oxidative / antioxidant imbalances change earlier than coal workers pneumoconiosis diagnostic X-ray imaging changes.