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目的 对病毒性肝炎患者血清中粒细胞 巨噬细胞集落刺激因子 (GM CSF)和白细胞介素 8(IL 8)水平检测 ,探讨GM CSF、IL 8与肝脏炎症活动及肝损害的关系 ,及二者在病毒性肝炎发病中的作用。方法 采用双抗体酶联免疫吸附法 (ELISA法 )检测了 5 9例病毒性肝炎患者血清中的GM CSF和IL 8水平 ,及患者血清中的ALT、AST、T BIL及白蛋白的水平。结果 5 9例病毒性肝炎患者血清中的GM CSF和IL 8水平较正常人显著升高 (P <0 0 1) ,并且GM CSF和IL 8水平与ALT、AST、T BIL及白蛋白的水平有明显的相关性。结论 GM CSF和IL 8与肝细胞的炎性损伤密切相关 ,在肝脏免疫损伤中可能起重要作用。提示检测血清中GM CSF及IL 8水平可以部分代表肝脏炎症活动及损伤程度。
Objective To detect the levels of GM-CSF and IL-8 in serum of patients with viral hepatitis, and to explore the relationship between GM CSF and IL-8 and hepatic inflammatory activity and liver damage, In the pathogenesis of viral hepatitis. Methods Serum levels of GM CSF and IL-8, serum ALT, AST, T BIL and albumin in 59 patients with viral hepatitis were detected by double antibody enzyme-linked immunosorbent assay (ELISA). Results Serum levels of GM CSF and IL-8 in 59 patients with viral hepatitis were significantly higher than those in normal controls (P <0.01), and the levels of GM CSF and IL-8 were positively correlated with the levels of ALT, AST, T BIL and albumin There is a clear correlation. Conclusion GM CSF and IL 8 are closely related to the inflammatory injury of hepatocytes, and may play an important role in the liver injury. Tip detection of serum GM CSF and IL 8 levels can partially represent the degree of liver inflammation and injury.