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目的观察三联疗法治疗消化性溃疡患者的临床疗效与安全性。方法选取医院收治的消化性溃疡患者100例,按照临床治疗方法的不同分为对照组与试验组各50例,对照组给予奥美拉唑、克拉霉素分散片及阿莫西林治疗,试验组给予奥美拉唑、左氧氟沙星片及阿莫西林胶囊治疗。治疗2周后,比较2组总有效率、Hp根除率、不良反应以及治疗成本。结果试验组总有效率为92.0%明显高于对照组的76.0%(P<0.05)。试验组Hp根除率为78.0%明显高于对照组的42.0%(P<0.05);2组治疗成本比较差异无统计学意义(P>0.05)。结论奥美拉唑、左氧氟沙星片及阿莫西林胶囊三联疗法能够在成本微调的情况下,显著提升临床治疗有效性及Hp根除率,控制不良反应情况,有效改善治疗安全性,值得临床推广应用。
Objective To observe the clinical efficacy and safety of triple therapy in patients with peptic ulcer. Methods 100 cases of peptic ulcer patients admitted in hospital were divided into control group and trial group according to the different clinical treatment methods. 50 cases in the control group were given omeprazole, clarithromycin dispersible tablets and amoxicillin. The experimental group Give omeprazole, levofloxacin tablets and amoxicillin capsules treatment. After 2 weeks of treatment, the total effective rate, Hp eradication rate, adverse reactions and treatment costs were compared between the two groups. Results The total effective rate of the experimental group was 92.0%, which was significantly higher than that of the control group (76.0%, P <0.05). The eradication rate of Hp in the experimental group was significantly higher than that in the control group (78.0% vs. 42.0%, P <0.05). There was no significant difference in the treatment costs between the two groups (P> 0.05). Conclusion Omeprazole, levofloxacin tablets and amoxicillin capsules triple therapy can significantly improve the effectiveness of clinical treatment and Hp eradication rate, adverse reactions, and improve the safety of treatment, worthy of clinical promotion and application.