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恶性肿瘤的侵袭和转移是导致病人死亡的主要原因。目前研究认为肿瘤细胞实现侵袭转移,必须首先穿越由细胞外基质(extracellular matrix,ECM)和基底膜(basement mam-brance,BM)组成的屏障。这个屏障主要由两部分组成:一是结构蛋白;二是糖氨聚糖(GAGs),其主要成分是硫酸乙酰肝素
Malignant tumor invasion and metastasis is the leading cause of death of patients. The current study suggests that invasion and metastasis of tumor cells must first cross the barrier composed of the extracellular matrix (ECM) and the basement membrane (BM). The barrier is mainly composed of two parts: one is the structural protein; the second is glycosaminoglycans (GAGs), the main component is heparan sulfate