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肺内吸入粉尘的量是尘肺发病的基础。一般来说,尘量与尘肺发病及X线胸片表现有高度相关,但X线胸片表现异常时纤维化已基本形成。因此,如何早期预报肺内粉尘沉积量,及时采取预防措施对防止尘肺病的发生、发展有一定的意义。肺内巨噬细胞的反应是人体吸入粉尘后最敏感的指标,许多研究证明吸入二氧化硅粉尘会引起肺泡巨噬细胞的增殖和崩解,吞噬硅尘的巨噬细胞(尘细胞)在肺内堆积和崩解是肺纤维化的最初环节。1974年国内许多研究单位曾用免疫学方法在矽肺大鼠血清内检出
Pulmonary dust inhalation is the basis of the incidence of pneumoconiosis. In general, the amount of dust and the incidence of pneumoconiosis and X-ray findings are highly correlated, but the abnormal performance of X-ray showed fibrosis has been basically formed. Therefore, how to forecast the amount of dust deposition in the lungs early and take timely preventive measures have some significance to prevent the occurrence and development of pneumoconiosis. The response of intrapulmonary macrophages is the most sensitive index after inhalation of dust. Many studies have shown that inhalation of silica dust can cause the proliferation and disintegration of alveolar macrophages. Phagocytosis of macrophages (dust cells) in the lung Accumulation and disintegration are the first steps in pulmonary fibrosis. In 1974, many domestic research units have used immunological methods detected in the serum of silicotic rats