论文部分内容阅读
目的 :了解我国艾滋病 (AIDS)患者机会性细菌感染状况及其病原菌对抗生素的敏感性。方法 :总结我院近 5年收治的 6 2例AIDS患者的临床资料 ,分析机会性细菌感染的发生情况及药敏试验结果。结果 :4 9例 (79.0 % )发生细菌感染 ,共分离出各种细菌 82株。感染部位依次为呼吸系统感染、消化系统感染、败血症和心血管系统感染。多系统及多种细菌感染率分别为 6 7.4 %和 4 2 .8% ,以细菌感染为直接致死原因者占死亡病例的 6 4 .3% (9/ 14 )。感染细菌依次为葡萄球菌属、真菌、大肠埃希菌和链球菌属。表现为对 β内酰胺类、大环内酯类、四环素类、氟喹诺酮类和氨基糖苷类抗菌药物多重耐药现象 ,真菌对咪唑类药物耐药。结论 :AIDS患者机会性细菌感染发生率高 ,是住院和致死的主要原因。多种细菌同时感染和多重耐药现象严重。应根据药敏试验结果选择抗菌药物
Objective: To understand the status of opportunistic bacterial infections and the sensitivity of pathogens to antibiotics in AIDS patients in China. Methods: To summarize the clinical data of 62 AIDS patients admitted to our hospital in the recent 5 years, and to analyze the incidence of opportunistic bacterial infections and drug susceptibility test results. Results: Bacterial infection occurred in 49 cases (79.0%), and 82 strains of various bacteria were isolated. Infections followed by respiratory infections, digestive infections, sepsis and cardiovascular infections. The rates of multi-system and multi-bacterial infections were 6 7.4% and 42.8% respectively, accounting for 6.43% (9/14) of the deaths due to bacterial infections as the direct cause of death. Infectious bacteria followed by Staphylococcus, fungi, Escherichia coli and Streptococcus. The performance of β-lactams, macrolides, tetracyclines, fluoroquinolones and aminoglycoside antibacterial multi-drug resistance phenomenon, fungi imidazole drugs resistant. Conclusion: The high incidence of opportunistic bacterial infection in AIDS patients is the main reason for hospitalization and death. Multiple bacterial infections and multiple drug resistance are serious at the same time. Antimicrobials should be selected based on susceptibility testing results