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为探讨抗天然II型胶原抗体 (抗NatII)在类风湿性关节炎 (RA )疾病活动中的意义。采用ELISA检测抗NatIIIgG ,用BNprospec特定蛋白分析仪检测C 反应蛋白 (CRP )和α1 酸性糖蛋白 (AAG ) ,Electa血沉仪测定红细胞沉降率 (ESR )。结果 6 0例RA患者血清抗NatIIIgG水平与ESR和血清CRP、AAG含量呈正相关 (相关系数r分别为 0 4 0 2、 0 2 6 8和 0 382 ) ,其中2 3例抗NatIIIgG阳性患者的ESR、CRP、AAG均显著高于抗NatIIIgG阴性者 (P <0 0 1)。抗NatIIIgG可作为RA疾病活动性指标之一。
To explore the role of anti-natural collagen II (anti-NatII) in rheumatoid arthritis (RA) disease activity. Anti-NatIIIgG was detected by ELISA, C-reactive protein (CRP) and α1 acid glycoprotein (AAG) were detected by BNprospec specific protein analyzer, and erythrocyte sedimentation rate (ESR) was measured by Electa ESR. Results The serum levels of anti-NatIIIgG in 60 RA patients were positively correlated with the levels of ESR and serum CRP and AAG (r = 0.402,0.268 and 0.382, respectively). Of the 23 patients with anti-NatIIIgG-positive ESR , CRP, AAG were significantly higher than anti-NatIIIgG negative (P <0.01). Anti-NatIIIgG can be used as an indicator of activity of RA disease.