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胆结石似乎是肢端肥大症患者应用长效生长抑素类似物 octreotide(OT)长期治疗的一种并发症。为了对胆石症的危险作进一步了解,作者在肢端肥大症患者和对照病人进行了 OT 治疗性试验,也对饥饿时胆囊体积和停用 OT 后胆结石的潜在可逆性进行了评估。
Gallstones appear to be a complication of the long-term treatment of octreotide (OT) in patients with acromegaly using the long-acting somatostatin analogue. In order to gain a better understanding of the risk of cholelithiasis, the authors conducted OT therapeutic trials in patients with acromegaly and control patients and also evaluated the gallbladder volume during starvation and the potential reversibility of gallstone after discontinuation of OT.