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人们认为,应用各种低剂量胰岛素静脉滴入治疗糖尿病酮症酸中毒(diabetic ketoacidosis,DKA),血糖下降的速度和酸中毒的控制,与以往惯用的较大剂量间歇皮下和静脉用药一样迅速。低剂量滴注也能导致低血糖和低血钾。开始时将胰岛素加入补液中,以每小时6～10U的速度滴入。应用此低剂量时,不必用负荷剂量,胰岛素的浓度是每1,000ml生理盐水内100U,亦即每小时6U。虽然曾报道偶可出现胰岛素抵抗,但在每小时6U的情况下很少发生。然而如2小时后血糖水平未见下降时,滴入速度应予加倍。当血糖降到250mg/dl或以下时,胰岛素滴入速度应减到每小时1～2U,同时补入液体可改为含氯化钠0.45%的5%葡萄糖盐水,将速度控制在150ml/h时很少发生低血糖。
It is believed that the use of various low-dose intravenous insulin in the treatment of diabetic ketoacidosis (DKA), the rate of blood glucose declines and the control of acidosis are as rapid as previous higher dose intermittent subcutaneous and intravenous administrations. Low-dose instillation can also cause hypoglycemia and hypokalemia. The beginning of the insulin added to rehydration, to 6 ~ 10U per hour drop in speed. With this low dose, it is not necessary to use a loading dose, and the concentration of insulin is 100 U per 1,000 ml of physiological saline, ie, 6 U per hour. Although it has been reported that even insulin resistance may occur, it rarely occurs in the case of 6U per hour. However, if 2 hours after the blood glucose levels have not dropped, the infusion rate should be doubled. When the blood glucose dropped to 250mg / dl or less, the insulin infusion rate should be reduced to 1 ~ 2U per hour, while filling the liquid can be changed to 0.45% sodium chloride, 5% glucose saline, the speed control at 150ml / h Hypoglycemia rarely occurs.