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环孢多肽A(CSA)是一种免疫调节剂,其作用机理与其抑制T辅助细胞机能有关。该药除应用于器官移植外,还可用于治疗某些血液病、皮肤病、结缔组织病。因其急慢性毒性发病率较高,因而只在常规方法治疗无效时才采用。血液病适应症虽CSA在大多数情况下对实质性器官移植有益,但在骨髓移植时也已成功地用于预防急性移植物抗宿主疾病(GVHD)。CSA与甲泼尼龙或甲氨蝶呤联用比其他任何药单用的疗效好。CSA与抗胸腺细胞球蛋白和甲泼尼龙联合治疗再生障碍性贫血也有效,它不仅对单纯红细胞再生障碍
Cyclosporin A (CSA) is an immunomodulatory agent whose mechanism of action is related to its inhibition of T helper cell function. In addition to the drug used in organ transplantation, but also for the treatment of certain blood diseases, skin diseases, connective tissue disease. Because of its high incidence of acute and chronic toxicity, and therefore only when the conventional method of treatment is invalid. Hematopathy indications Although CSA is beneficial for substantial organ transplantation in most cases, it has also been successfully used to prevent acute graft-versus-host disease (GVHD) during bone marrow transplantation. CSA with methylprednisolone or methotrexate in combination with any other drug alone with good effect. CSA and anti-thymocyte globulin and methylprednisolone treatment of aplastic anemia is also effective, it not only for simple red cell aplasia