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目的探讨普米克令舒联合西咪替丁辅助治疗小儿毛细支气管炎(毛支)的疗效及安全性。方法2004-01—2006-03,将浙江省苍南县第二人民医院收治的175例毛支患儿分为治疗A组、治疗B组和对照组。3组均采用综合治疗,利巴韦林10～15mg/(kg.d)静滴;治疗A组加用普米克令舒雾化吸入治疗。用法为每次1mL(含布地奈德0.5mg),加生理盐水至2～3mL,由空气压缩泵雾化吸入,每日3次,每次吸入10～15min,疗程为5～7d;治疗B组,在治疗A组的基础上,加用西咪替丁,10～15mg/(kg.d),用生理盐水稀释静滴,疗程7d。对3组疗效,以及症状、体征持续时间,住院时间等进行对照评价。结果治疗B组治愈率明显提高,哮鸣音、湿啰音、咳嗽消失及住院时间明显缩短,与治疗A组及对照组比较差异有显著性(P<0.05或P<0.01)。结论普米克令舒联合西咪替丁辅助治疗小儿毛支,可缩短病程,提高治愈率,疗效确切,使用安全。
Objective To investigate the efficacy and safety of pulmicort combined with cimetidine in the treatment of pediatric bronchiolitis (bronchiolitis). Methods From January 2004 to June 2006, 175 cases of children with bronchitis treated in Second People’s Hospital of Cangnan County, Zhejiang Province were divided into treatment A group, treatment B group and control group. Three groups were treated with combination therapy, ribavirin 10 ~ 15mg / (kg.d) intravenous infusion; treatment A group with pulmicort respirator inhalation therapy. Usage for each 1mL (budesonide 0.5mg), plus normal saline to 2 ~ 3mL inhaled by air compression pump inhalation, 3 times a day, each inhalation 10 ~ 15min, course of treatment is 5 ~ 7d; Treatment B Group, in the treatment group A, based on the addition of cimetidine, 10 ~ 15mg / (kg.d), diluted with saline, intravenous infusion, the treatment of 7d. The three groups of efficacy, as well as symptoms, signs of duration, length of stay and other control evaluation. Results The cure rate of group B was significantly higher than that of group A and control group (P <0.05 or P <0.01). The wheeze, dampness, cough and disappearance of cough were significantly shortened. Conclusions Pulmicort respules combined with cimetidine adjuvant treatment of children hair branch, can shorten the course of disease, improve the cure rate, curative effect is exact, safe to use.