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目的比较左氧氟沙星与头孢呋辛联合阿奇霉素治疗社区获得性肺炎(CAP)的临床疗效、细菌清除率和安全性。方法将57例社区获得性肺炎随机分为左氧氟沙星治疗组(31例)和头孢呋辛联合阿奇霉素对照组(26例),观察两组患者的临床疗效,细菌清除率和不良反应。结果57例CAP患者中左氧氟沙星租治疗的痊愈率和有效率分别为70.96%和93.54%,细菌清除率为88.89%,药物不良反应发生率为12.90%;对照组治疗的痊愈率和有效率分别为69.23%和92.31%,细菌清除率为85.71%,药物不良反应发生率为11.54%。两组比较差异无统计学意义,平均疗程、住院天数差异亦无统计学意义。结论左氧氟沙星治疗CAP临床疗效确切,患者依从性好,药物不良反应较低,值得临床推广应用。
Objective To compare the clinical efficacy, the clearance rate and the safety of levofloxacin and cefuroxime combined with azithromycin in the treatment of community-acquired pneumonia (CAP). Methods 57 patients with community-acquired pneumonia were randomly divided into levofloxacin treatment group (31 cases) and cefuroxime plus azithromycin control group (26 cases). Clinical efficacy, bacterial clearance and adverse reactions were observed in two groups. Results The cure rate and effective rate of Levofloxacin in 57 CAP patients were 70.96% and 93.54% respectively, the bacterial clearance rate was 88.89% and the adverse drug reaction rate was 12.90%. The cure rate and effective rate of the control group were 69.23% and 92.31%, the bacterial clearance rate was 85.71% and the incidence of adverse drug reactions was 11.54%. The difference between the two groups was not statistically significant, the average course of treatment, hospital days, the difference was not statistically significant. Conclusion Levofloxacin treatment of CAP clinical curative effect, patients with good compliance, low adverse drug reactions, it is worthy of clinical application.