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霍奇金淋巴瘤(HL)的典型形态特征表现为炎症背景中存在一系列形态谱系的肿瘤细胞,包括单核霍奇金细胞、多核Reed-Sternberg(R-S)细胞和木乃伊细胞。但是,关于这些肿瘤细胞在形态发生过程中所经历的细胞生物学及基因表达改变了解甚少。目前研究发现病毒蛋白在急性或潜伏感染细胞
The typical morphological features of Hodgkin’s lymphoma (HL) are tumor cells with a series of morphological lineages in the inflammatory background, including mononuclear Hodgkin’s cells, polynuclear Reed-Sternberg (R-S) cells and mummified cells. However, little is known about the changes in cell biology and gene expression that these tumor cells undergo during their morphogenesis. The current study found that viral proteins in acute or latent infected cells