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自从显带技术问世以来,人类肿瘤染色体的不随机改变已被记载.最近作者利用G显带技术对6例卵巢癌进行了细胞遗传学研究,发现常见的染色体重排是1(4例)、3(6例)、6(2例)、7(2例)、17(8例)号染色体,尤以3p-标记染色体最为常见.6个病例的诊断均靠病理学检查,染色体的制备取材于原发卵巢腺癌或腹水,前者在McCoy培液中剪碎制成细胞悬液,不经体外培养,直接制片,胰酶-吉姆萨显带处理,尽可能多检查一些细胞(不能少于10
Non-random changes in human tumor chromosomes have been documented since the advent of banding technology.6 The authors recently performed cytogenetic studies on 6 ovarian cancers using G-banding and found that 1 (4) common chromosomal rearrangements, 3 (6 cases), 6 (2 cases), 7 (2 cases) and 17 (8 cases) chromosomes, especially the 3p-labeled chromosomes were the most common.The diagnosis of 6 cases were based on pathological examination, chromosome preparation In the primary ovarian adenocarcinoma or ascites, the former was cut into cells in McCoy’s culture medium suspension, without in vitro culture, direct production, trypsin-Giemsa banding, as many as possible to check some of the cells (not less At 10