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目的研究烟草Nicotiana tabacum叶中的西松烷二萜类化学成分。方法采用柱色谱技术对烟草的95%乙醇提取物进行分离纯化,采用波谱技术结合化学方法进行结构鉴定。结果从烟草提取物中分离得到了5个西松烷二萜类成分,分别鉴定为(1R,3E,7E,10S,11E)-3,7,11-cem-bratriene-10,15-diols(1)、(1S,2E,4S,6R,7E,10E,12S)-2,7,10-cembratriene-4,6,11-triol(2)、(1S,2E,4R,6R,7E,10E,12S)-2,7,10-cembratriene-4,6,11-triol(3)、(1S,2E,4S,6R,7E)-4,6,11-trihydroxy-1-isopropyl-4,8-dimethylpentadeca-2,7-dien-12-one(4)、(1S,2E,4R,6R,7E,11S,12S)-11,12-epoxy-2,7-cembradiene-4,6-diol(5)。结论化合物1为1个新化合物,命名为烟叶二萜B;化合物4首次在植物中发现,为1个新的天然产物。
Objective To study the chemical composition of cembranoid diterpenoids in Nicotiana tabacum leaves. Methods The 95% ethanol extract of tobacco was separated and purified by column chromatography. The chemical structure was identified by spectroscopy and chemical methods. Results Five cembranoid diterpenoids were isolated from tobacco extracts and identified as (1R, 3E, 7E, 10S, 11E) -3,7,11-cem-bratriene-10,15-diols (1S, 2E, 4S, 6R, 7E, 10E, 12S) -2,7,10- cembratriene-4,6,11- triol (2), (1S, 2E, 4R, 6R, 7E, 10E, 12S) -2,7,10-cembratriene-4,6,11-triol (3), (1S, 2E, 4S, 6R, 7E) -4,6,11-trihydroxy- dimethylpentadeca-2,7-dien-12-one (4), (1S, 2E, 4R, 6R, 7E, 11S, 12S) -11,12-epoxy-2,7-cembradiene-4,6-diol ). Conclusion Compound 1 is a new compound named diterpenoid B of tobacco leaf. Compound 4 was found in plants for the first time and is a new natural product.