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目的：研究重症胰腺炎（ａｃｕｔｅｈａｅｍｏｒｒｈａｇｉｃ－ｎｅｃｒｏｔｉｚｉｎｇｐａｎｃｒｅａｔｉｔｉｓ，ＡＨＮＰ）胰组织血流的变化和二十碳烯酸类产物的异常代谢，探讨大黄素和善得定对这些指标的影响。方法：以牛磺胆酸钠诱发大鼠ＡＨＮＰ模型、计算机化血流仪测定胰组织动态血流变化、放免法测定血前列腺素Ｅ２（ｐｒｏｓｔａｇｌａｎｄｉｎＥ２，ＰＧＥ２）、６－酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ｐｒｏｓｔａｇｌａｎｄｉｎＦ１α，６－ｋｅｔｏ－ＰＧＦ１α）、血栓素Ｂ２（ｔｈｒｏｍｂｏｘａｎｅＢ２，ＴＸＢ２）等。结果：ＡＨＮＰ初期胰组织血流显著降低；与非治疗组相比，大黄素组胰组织血流降低被显著阻遏；善得定组在发病前即因给药而胰组织血流降低，但发病后胰组织血流降低值较之于非治疗组显著减轻。非治疗组ＴＸＢ２显著增高，发病６ｈ达假手术组的４．５倍；６－ｋｅｔｏ－ＰＧＦ１α与ＰＧＥ２则呈下降趋势。大黄素或善得定组上述二十碳烯酸类异常代谢明显被纠正。病理组织学评分及电镜超微结构观察示给药组腺细胞坏死表现等显著轻于非治疗组。药物治疗两组１２ｈ的生存率显著高于非治疗组。结论：大黄素或善得定可显著改善ＡＨＮＰ初期胰缺血，其机制可能是抑制ＡＨ
Objective: To study the changes of pancreatic blood flow and abnormal metabolism of eicosenoic acid in patients with severe acute pancreatitis (AHNP), and to explore the effects of emodin and good serum on these indexes. Methods: The rat model of AHNP was induced by sodium taurocholate and the dynamic blood flow of pancreatic tissue was measured by computerized flowmeter. The levels of prostaglandin E2 (PGE2), 6-keto-prostaglandin F1α (6- keto-prostaglandin F1α, 6-keto-PGF1α), thromboxane B2 (TXB2) and the like. Results: Compared with non-treatment group, the decrease of blood flow in pancreatic tissue was significantly suppressed in untreated group, and the blood flow in pancreatic tissue was decreased before administration Post-pancreatic blood flow reduction was significantly reduced compared with non-treatment group. TXB2 in non-treatment group was significantly higher than that in sham operation group at 6 hours after onset, and 6-keto-PGF1α and PGE2 showed a decreasing trend. Emodin or good set group of eicosenoic abnormal metabolism was significantly corrected. Histopathological score and electron microscopy showed that the apoptotic cells in the treated group were significantly lighter than those in the untreated group. The 12-h survival rate of the two groups was significantly higher than that of the non-treatment group. Conclusion: Emodin or good dose can significantly improve the early AHNP pancreatic ischemia, the mechanism may be inhibited AH