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异体骨髓移植术临床应用的经验证明,给患者注入2.8×10~8～8.3×10~8/kg骨髓细胞可以获得治疗效果。为了得到这样数量的细胞需要抽取骨髓悬液400～800ml。作者研究了76名献髓者在抽吸骨髓之前、当时、结束后立即以及24小时后的一般状态、血液动力学指标(脉搏、血压)、心电图、外周血血红蛋白输氧功能、酸硷平衡、血浆蛋白、胆红素、钾、铁的含量及血象等。献髓者住院,局麻下在髂骨胸骨多次(8～60次)抽吸,抽取骨髓液240～675 ml(不包括抗凝剂)。全部献髓者在穿刺开始时均紧张惊慌,有56名血压升高10～50mmHg,心动过速(80～112次/分)。经第1次和2～3次后就镇静了。其中70%血压脉搏趋向正常,抽吸结束时80%恢复正常,20%经6～20小时后恢复正常。全部献髓者在抽得骨髓同时出现不
The experience of clinical application of allogeneic bone marrow transplantation proves that the treatment effect can be obtained by infusing 2.8 × 10 ~ 8 ~ 8.3 × 10 ~ 8 / kg bone marrow cells into patients. In order to obtain this amount of cells, a bone marrow suspension of 400 to 800 ml is required. The authors studied the general state of hemodynamics (pulse, blood pressure), electrocardiogram, peripheral blood hemoglobin oxygen transport function, acid-base balance, blood plasma levels before, during, immediately after, and immediately after, Protein, bilirubin, potassium, iron content and blood and so on. Markers were hospitalized under local anesthesia in the iliac crest many times (8 to 60 times) aspiration, extraction of bone marrow fluid 240 ~ 675 ml (not including anticoagulants). All of the donors were nervous and alarmed at the start of the puncture. Fifty-six blood pressure was increased by 10-50 mmHg and tachycardia (80-112 beats / min). After the first and 2 to 3 times after the sedation. 70% of the blood pressure pulse to normal, 80% at the end of suction back to normal, 20% returned to normal after 6 to 20 hours. All donation of bone marrow at the same time not appear