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目的:探讨参芪地黄汤辅助治疗IgA肾病的疗效。方法:采用平行随机对照临床研究,将100例IgA肾病患者随机分为治疗组和对照组各50例。对照组予常规治疗,治疗组在对照组基础上予参芪地黄汤辅助治疗,两组均治疗3个月;观察比较两组治疗前、治疗后1、2、3个月的24 h尿蛋白定量、血肌酐、肾小球滤过率变化情况,并评价比较两组临床疗效。结果:治疗组总有效率为88.0%,对照组总有效率为66.0%,治疗组优于对照组,差异有统计学意义(P<0.05);两组临床疗效比较,差异有统计学意义(P<0.05),治疗组疗效优于对照组。治疗后3个月比较,治疗组24 h尿蛋白定量低于对照组,差异有统计学意义(P<0.05);治疗后2、3个月与治疗前比较,两组24 h尿蛋白定量均降低,差异均有统计学意义(P<0.05)。治疗后3个月比较,治疗组血肌酐低于对照组,差异有统计学意义(P<0.05);治疗后3个月与治疗前比较,两组血肌酐均降低,差异均有统计学意义(P<0.05)。治疗后3个月比较,治疗组肾小球滤过率高于对照组,差异有统计学意义(P<0.05);治疗后2、3个月两组肾小球滤过率均较治疗前增加,差异均有统计学意义(P<0.05)。结论:参芪地黄汤辅助治疗IgA肾病有较好疗效,有利于改善患者肾功能。
Objective: To investigate the effect of Shenqi Dihuang decoction on IgA nephropathy. Methods: A parallel randomized clinical trial of 100 patients with IgA nephropathy were randomly divided into treatment group and control group of 50 cases. The control group was given routine treatment. The treatment group was treated with Shenqi Dihuang decoction on the basis of the control group, and both groups were treated for 3 months. The levels of 24 h urinary protein before treatment, 1,2,3 months after treatment were observed and compared Quantitative, serum creatinine, glomerular filtration rate changes, and to evaluate the clinical efficacy of two groups. Results: The total effective rate was 88.0% in the treatment group and 66.0% in the control group, and the difference between the two groups was statistically significant (P <0.05). The difference between the two groups was statistically significant (P < P <0.05), the treatment group than the control group. After 3 months of treatment, the 24 h proteinuria in the treatment group was lower than that in the control group, the difference was statistically significant (P <0.05); 24 months after treatment, compared with before treatment, Reduce, the difference was statistically significant (P <0.05). After 3 months of treatment, the serum creatinine in the treatment group was lower than that in the control group (P <0.05), and the levels of serum creatinine in the two groups were significantly decreased at 3 months after treatment (P <0.05). The glomerular filtration rate of the treatment group was higher than that of the control group at 3 months after treatment (P <0.05), and the glomerular filtration rate of the two groups at 2 and 3 months after treatment was significantly higher than that before treatment Increase, the difference was statistically significant (P <0.05). Conclusion: Shenqi Dihuang Decoction adjuvant treatment of IgA nephropathy has a good effect, help to improve renal function in patients.