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目的探讨毛细支气管炎合并高凝状态及肝素抗凝治疗的有效性。方法测定2011年10月~2012年6月四川省简阳市中医院儿科收治的100例毛细支气管炎患儿治疗前后的D-二聚体(D-Dimer)、抗凝血酶Ⅲ(AT-Ⅲ)、凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血时间(APTT)、纤维蛋白原(Fbg)及氧饱和度(SaO2),并进行对比。结果100例毛细支气管炎患儿中50例的D-Dimer升高,治疗前50例患儿的AT-Ⅲ活性及SaO2明显降低,TT、APTT明显缩短。经肝素治疗后,50例治疗组患儿的D-Dmuer下降、SaO2升高、TT延长、Fbg下降。结论毛细支气管炎存在高凝状态；肝素抗凝治疗对毛细支气管炎合并高凝状态是有效的。“,”Objective To explore the hypercoagulable state of bronchiolitis and the ef ective anticoagulation treatment with heparin. Method D-Dimer、AT-Ⅲ、TT、PT、APTT、 Fbg and SaO2 levels were measured and compared in bronchiolitis before and after treatment with heparin. Results D-Dimer level was increased in 50 of 100 cases of bronchiolitis patients. In 50 patients with bronchiolitis before treatment with heparin, AT-Ⅲ And SaO2 levels were significantly lower and TT、APTT were remarkably shorter than in normal group. In 50 patients with bronchiolitis after treatment with heparin, D-Dimer and Fbg levels were significantly reduced, while SaO2 and TT levels were obviously increased. Conclusions There exists hypercoagulable state in bronchiolitis; Anticoagulation treatment with heparin in hypercoagulable state of bronchiolitis were ef ective.