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目的探讨β-连环素与E-钙粘素在肝癌中的表达及与临床病理学的意义。方法采用S-P免疫组化法检测β-连环素及E-钙粘素在72例肝癌的表达。结果在肝癌中β-连环素(76.4%)和E-钙粘素异常表达(61.1%)均明显高于癌周组织与肝硬化(P<0.001)。β-连环素或E-钙粘素异常表达在肝癌中分化呈明显相关(P<0.001)。E-钙粘素异常表达在门静脉有无癌栓中呈明显相关(P<0.01)。结论β-连环素与E-钙粘素异常表达可能参与肝癌发生、发展,并与肝癌的临床生物特性有一定关系。
Objective To investigate the expression of β-catenin and E-cadherin in hepatocellular carcinoma and its clinical significance. Methods The expression of β-catenin and E-cadherin in 72 cases of hepatocellular carcinoma was detected by S-P immunohistochemistry. Results The abnormal expression of β-catenin (76.4%) and E-cadherin (61.1%) in HCC was significantly higher than that in peritumor and liver cirrhosis (P <0.001). Abnormal expression of β-catenin or E-cadherin was significantly correlated with differentiation in HCC (P <0.001). The abnormal expression of E-cadherin in the portal vein tumor thrombus was significantly correlated (P <0.01). Conclusion The abnormal expression of β-catenin and E-cadherin may be involved in the occurrence and development of hepatocellular carcinoma and has certain relationship with the clinical biological characteristics of hepatocellular carcinoma.