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涎腺腺样囊性癌(ACC)是一种发病率较高的涎腺恶性肿瘤,具有嗜神经侵袭和肺转移特性,其发生和发展是多个基因及产物共同作用的结果。传统治疗的效果并不理想,大量的临床研究已初步证实,ACC的癌细胞中存在多个抑癌基因启动子区的高甲基化,从而使细胞失去调控呈无限增殖。目前所研究的基因大多涉及癌细胞的发生、黏附、周期调控和信号转导等方面,对这些基因的研究关系到肿瘤的诊断、治疗及预后评价。
Salivary adenoid cystic carcinoma (ACC) is a malignant salivary gland tumor with a high incidence and has the characteristics of neuropathic and lung metastasis. The occurrence and development of salivary adenoid cystic carcinoma (ACC) are the result of multiple genes and products together. The effect of traditional treatment is not ideal. A large number of clinical studies have initially confirmed that hypermethylation of multiple tumor suppressor gene promoters exists in ACC cancer cells, resulting in unlimited proliferation of cells. At present, most of the genes studied are involved in the occurrence, adhesion, cycle regulation and signal transduction of cancer cells. The research of these genes is related to the diagnosis, treatment and prognosis of tumors.