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目的观察中药六味安消联合左氧氟沙星方案根除Hp的疗效。方法选择Hp阳性慢性胃炎250例,随机分为A组128例和B组122例,A组口服埃索美拉唑20mg加左氧氟沙星200mg,2次/d,1周,六味安消胶囊2.0g,3次/d,2周。B组口服埃索美拉唑片20mg加阿莫西林分散片1g加克拉霉素500mg,2次/d,1周。疗程结束1个月后行14C尿素呼气验检测Hp。结果A组和B组HP根除率分别为84.2%和73.0%,差异有显著性(P>0.05);A组和B组临床有效率分别为97.5%和94.8%,差异无显著性(P>0.05)。结论六味安消联合左氧氟沙星疗法比传统标准三联疗法的Hp根除率高,且与传统三联临床疗效相当,可作为根除Hp的治疗方案之一。
Objective To observe the efficacy of traditional Chinese medicine Liuwei Anshun combined with levofloxac in the eradication of Hp. Methods A total of 250 Hp-positive chronic gastritis patients were randomly divided into group A (n = 128) and group B (n = 122). Group A received omeprazole 20 mg plus levofloxacin 200 mg twice daily for six weeks, 3 times / d, 2 weeks. Group B oral esomeprazole tablets 20mg plus amoxicillin dispersible tablets 1g plus clarithromycin 500mg, 2 times / d, 1 week. One month after the end of treatment line 14C urea breath test to detect Hp. Results The eradication rates of HP in group A and group B were 84.2% and 73.0%, respectively, with significant difference (P> 0.05). The clinical effective rates in group A and group B were 97.5% and 94.8% respectively, with no significant difference (P> 0.05). Conclusions Liuwei Anshixing combined with levofloxacin has higher Hp eradication rate than the traditional triple therapy and its clinical efficacy is comparable with that of traditional triple therapy and may be used as one of the treatment options for the eradication of Hp.