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几个研究现已证实,使用口服避孕丸与深静脉血栓形成之间存在着因果关系。用口服避孕丸的妇女发生术后深静脉血栓形成的危险较正常增加5-6倍。有报道指出,用口服避孕丸的妇女,其血浆抗凝血酶Ⅲ的浓度低于对照病人。血浆抗凝血酶Ⅲ是一个分子量约为60,000的α_2球蛋白,它的主要作用是抑制在凝血过程中占有关键地位的激活了的X 因子。本工作在两组做外科手术的年轻妇女预先测定了血浆抗凝血酶Ⅲ的活性,以期阐明用口服避孕丸与血浆抗凝血酶Ⅲ活性以及手术后深静脉血栓形成之间的关系。
Several studies have now confirmed a causal relationship between the use of oral contraceptive pills and deep venous thrombosis. Women who take oral contraceptive pills have a 5-6-fold increased risk of postoperative deep venous thrombosis compared with normal. It has been reported that women taking oral contraceptive pills have a lower plasma antithrombin III concentration than control patients. Plasma antithrombin III is an alpha 2-globulin with a molecular weight of about 60,000. Its primary role is to suppress activated factor X, which plays a key role in the clotting process. This work in two groups of young women undergoing surgery preoperative determination of plasma antithrombin Ⅲ activity in order to clarify the use of oral contraceptive pills and plasma antithrombin Ⅲ activity and postoperative deep venous thrombosis relationship.