松弛肽在妊娠期建立肾脏反应方面起作用

• 作 者: Smith M.C. Murdoch A.P. Danielson L.A. 朱晓明
• 机 构: School of Surgical and Reproductive Sciences University of Newcastle uponTyne,Newcastle uponTyne Ty
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2006年11期
• 关键词: 松弛肽 妊娠期 肾脏 啮齿目动物 克分子浓度 妊娠早期 卵巢 肌酐 肾功能 基线

Women with normal ovarian function (n = 9) and women who conceived with ovum donation (no circulating relaxin; n = 9)- had serial measurements of renal function made during the first trimester of pregnancy by using 24- hour creatinine clearance (CrCl) and plasma osmolality (Posm). All pregnancies were associated with increasing CrCl and reduced Posm, but the change from baseline was significantly greater in the women with normal ovarian function, indicating that in contrast to the rodent model, other factors in addition to circulating relaxin contribute to gestational renal adaptation to human pregnancy.

Women with normal ovarian function (n = 9) and women who conceived with ovum donation (no circulating relaxin; n = 9) - had serial measurements of renal function made during the first trimester of pregnancy by using 24-hour creatinine clearance (CrCl) and plasma osmolality (Posm). All pregnancies were associated with increasing CrCl and reduced Posm, but the change from baseline was significantly greater in the women with normal ovarian function, indicating that in contrast to the rodent model, other factors in addition to circulating relaxin contribute to gestational renal adaptation to human pregnancy.