一例放射性工作者外周血染色体畸变的鉴别诊断探讨

• 作 者: 毛玉蟾 邱雪英
• 机 构: 广西卫生防疫站,广西卫生防疫站 南宁,南宁
• 出 处: 遗传
• 发表日期: 1986年06期
• 关键词: 小体 微小体 异常核型 小染色体 细胞遗传学 圆点状 性染色体 鉴别诊断 性染色体异常 核型分析

在对X线工作者体检时,我们发现一例遗传性染色体异常者。经核型分析为嵌合型:46,XX/47,XX,+?。在异常核型中除44条常染色体和2条性染色体外,还多1条似乎像小染色体(以下简称“小体”)。含有“小体”的细胞占分析细胞数的60％以上。“小体”形态可呈圆点状,有时似微小体或小G(图1、2、3、4)。对受检者连续观察3年,并对其双亲作了细胞遗传学调查。现将观察结果报告如下。

In the X-ray workers physical examination, we found a case of hereditary chromosomal abnormalities. The karyotype was chimeric: 46, XX / 47, XX, + ?. In the abnormal karyotype in addition to 44 autosomal and 2 sex chromosomes, one more seems like a small chromosome (hereinafter referred to as “body”). Cells containing “small bodies” accounted for more than 60% of the analyzed cells. “Small” form can be dot-shaped, sometimes like a small body or small G (Figure 1,2,3,4). The subjects were continuously observed for 3 years, and their parents were cytogenetically investigated. The observations are reported below.