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目的探讨高血压人群叶酸营养水平与血清炎症因子的关系,为叶酸防治慢病提供科学依据。方法纳入2014年1月至2014年8月在云南省弥勒县人民医院体检中发现的未经治疗的高血压患者119例为研究对象,清晨空腹抽取静脉血分离血清,检测血清叶酸和hs-CRP、TNF-α、IL-1β、IL-6等炎症因子,分析血清叶酸浓度和炎症因子之间的关联性。结果高血压病人群中,血清叶酸浓度高者,IL-1β、IL-6均较低,差异有统计学意义(P<0.05);两组间的血脂及其他指标的差异无统计学意义(P>0.05);血清叶酸浓度与IL-1β、IL-6呈负相关关系(χ2=-0.395、-0.203,P<0.01、0.05),与TNF-α、hs-CRP的相关系数无统计学意义。结论高血压人群的血清叶酸浓度与炎症指标明显相关,血清叶酸浓度高者其炎症指标IL-1β、IL-6较低,提示良好的叶酸营养状况有助于降低高血压人群的慢性炎症水平。
Objective To investigate the relationship between folic acid nutrition and serum inflammatory factors in hypertensive population and provide a scientific basis for the prevention and treatment of chronic disease by folic acid. Methods A total of 119 untreated patients with hypertension were included in the physical examination of Mile County People’s Hospital of Yunnan Province from January 2014 to August 2014. Serum folic acid and hs-CRP , TNF-α, IL-1β, IL-6 and other inflammatory factors, the correlation between serum folate concentration and inflammatory cytokines was analyzed. Results Among the hypertensive patients, the serum folate levels were higher, the levels of IL-1β and IL-6 were lower, the difference was statistically significant (P <0.05). There was no significant difference in serum lipids and other indexes between the two groups (P> 0.05). There was a negative correlation between serum folate concentration and IL-1β and IL-6 (χ2 = -0.395, -0.203, P <0.01, 0.05) significance. Conclusions Serum folic acid concentration is significantly correlated with inflammation in hypertensive population. Serum levels of folic acid are associated with lower levels of IL-1β and IL-6, suggesting that good folic acid nutrition may help to reduce chronic inflammation in hypertensive population.