【摘 要】
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Objective:To study the effects of total flavone of Abelmoschl Manihot L. Medic (TFA) on the function of platelets and to explore its mechanism. Methods: Rat mod
【机 构】
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Department of Pharmacology
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Objective:To study the effects of total flavone of Abelmoschl Manihot L. Medic (TFA) on the function of platelets and to explore its mechanism. Methods: Rat models of artery-veins bypassing thrombus formation were used. The platelets of rabbits were collected. Platelet aggregation was induced by collagen and intracellular calcium ion concentration ([Ca2+ ]i) was assayed by Fura-2 method. Results: TFA (25, 50,100 mg/kg) significantly and dose-dependently reduced the weight of thrombus. TFA (0. 025, 0.05, 0.1 mg/mi) possessed dose-dependant inhibitory effects on rabbits' platelet aggregation induced by collagen. TFA significantly reduced the resting and CaCl2-induced increase of free intracellular calcium concentration ([Ca2+ ]i) in rabbit platelet in vitro. Conclusion: TFA has an antiplatelet effect via the inhibition on the influx of Ca2+ .
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