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目的探讨人乳头瘤病毒(HPV)、单纯疱疹病毒Ⅱ型(HSVⅡ)、沙眼衣原体(CT)和支原体(UU)4种病原微生物感染与子宫颈病变关系。方法采用PCR荧光法检测4种病原微生物的DNA,并同时做液基细胞学检查。结果HPV、HSVⅡ、CT、UU、HPV+HSVⅡ、CT+UU、HPV+CTDNA检出率分别为17.8%、10.3%、21%、15.9%、3.3%、2.9%、1.3%。细胞学诊断阳性者146例,不典型鳞状上皮细胞病变(ASCUS)、低度鳞状上皮内病变(LSIL)、高度鳞状上皮内病变(HSIL)、鳞状细胞癌(SCC)的HPV感染率分别为15.38%、71.11%、77.14%、100%。结论HPV感染是宫颈癌、宫颈鳞状上皮内瘤变的高危因素;HPV、HSVⅡ、CT、UU感染是宫颈糜烂的主要病原体。这几种病原微生物合并感染时,由于其相互作用,可促进宫颈病变的进程,导致宫颈癌的发生。
Objective To investigate the relationship between human papillomavirus (HPV), herpes simplex virus type 2 (HSV Ⅱ), Chlamydia trachomatis (CT) and mycoplasma (UU) in four pathogenic microorganisms and cervical lesions. Methods DNA of four kinds of pathogenic microorganisms was detected by PCR fluorescence method and liquid-based cytology was performed at the same time. Results The detection rates of HPV, HSV Ⅱ, CT, UU, HPV + HSV Ⅱ, CT + UU and HPV + CTDNA were 17.8%, 10.3%, 21%, 15.9%, 3.3%, 2.9% and 1.3%, respectively. There were 146 cases of cytological diagnosis positive, ASCUS, LSIL, HSIL, SCC HPV infection Rates were 15.38%, 71.11%, 77.14%, 100% respectively. Conclusion HPV infection is a high risk factor for cervical cancer and cervical squamous intraepithelial neoplasia. HPV, HSV Ⅱ, CT and UU infection are the main pathogens of cervical erosion. These several pathogenic microorganisms combined infection, due to its interaction, can promote the process of cervical lesions, leading to cervical cancer.