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目的:探讨抗心磷脂抗体(ACA)与脑卒中的关系,为临床对脑卒中的诊断和预防提供依据。方法:用酶联免疫吸附试验(ELISA)测定378例脑卒中患者血清中的抗心磷脂抗体水平。结果:①脑梗死患者ACA的阳性率(31·6%)明显高于脑出血患者的ACA阳性率(9·38%)(P<0·001);②年龄<30岁和年龄≥30且≤50岁的脑出血、脑梗死患者ACA阳性率均显著高于50岁以上的脑出血、脑梗死患者ACA阳性率。结论:①在脑卒中患者中,ACA对脑梗死的发生比对脑出血的发生更为密切;②ACA与青、中年的脑卒中患者关系密切,及早进行ACA检测将有助于脑卒中的预防和诊治。
Objective: To investigate the relationship between anti-cardiolipin antibodies (ACA) and stroke in order to provide evidence for clinical diagnosis and prevention of stroke. Methods: The levels of anti-cardiolipin antibodies in serum of 378 stroke patients were determined by enzyme linked immunosorbent assay (ELISA). Results: ① The positive rate of ACA in cerebral infarction patients (31.6%) was significantly higher than that of cerebral hemorrhage patients (9.38%) (P <0.001) The positive rates of ACA in patients with cerebral hemorrhage and cerebral infarction ≤50 years old were significantly higher than those of patients with cerebral hemorrhage and cerebral infarction above 50 years old. Conclusions: ①In the stroke patients, the occurrence of cerebral infarction is more closely related to cerebral hemorrhage than ACA; ②ACA is closely related to the stroke patients in middle-aged and younger age, and the early detection of ACA will be helpful for the prevention of stroke And diagnosis and treatment.