论文部分内容阅读
目的探讨谷氨酰胺与无乳糖配方奶喂养对坏死性小肠结肠炎早产儿免疫功能、胃肠激素的影响。方法选择56儿坏死性小肠结肠炎患儿为研究对象,采用随机数字表法分为观察组与对照组各28例,两组患儿均给予综合对症治疗,在此基础上,观察组给予谷氨酰胺与无乳糖配方奶喂养,对照组给予谷氨酰胺与早产儿配方奶喂养。喂养14d后,比较两组患儿免疫功能、胃肠激素、体质量变化及治疗效果。结果免疫功能:观察组Ig A、Ig G、Ig M、CD4+、CD4+/CD8+均明显高于对照组,CD8+明显低于对照组,差异有统计学意义(t=5.482~6.271,P<0.05);胃肠激素:观察组胃动素、胃泌素水平明显高于对照组(t=7.178~8.211,P<0.05);体质量:观察组体质量明显高于对照组(t=2.340,P<0.05)。结论谷氨酰胺与无乳糖配方奶喂养有助于改善儿坏死性小肠炎患儿免疫功能及胃肠功能,促进患儿健康成长。
Objective To investigate the effects of glutamine and lactose-free formula on immune function and gastrointestinal hormones in preterm infants with necrotizing enterocolitis. Methods Fifty-six children with necrotizing enterocolitis were selected as study subjects. The patients were randomly divided into observation group and control group with 28 cases in each group. Children in both groups were given comprehensive symptomatic treatment. On this basis, the observation group was given Valley Aminoamide and lactose-free formula fed, control group given glutamine and preterm infant formula feeding. After 14 days of feeding, immune function, gastrointestinal hormones, body weight changes and therapeutic effects were compared between the two groups. Results Immunity: The levels of Ig A, Ig G, Ig M, CD4 +, CD4 + / CD8 + in the observation group were significantly higher than those in the control group, and the levels of CD8 + in the observation group were significantly lower than those in the control group (t = 5.482-6.271, (T = 7.178 ~ 8.211, P <0.05). The body mass of the observation group was significantly higher than that of the control group (t = 2.340, P <0.05). Conclusion Glutamine and lactose-free formula feeding can help to improve children’s immune function and gastrointestinal function in children with necrotizing enteritis and promote the healthy growth of children.