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Objective:To evaluate the antihyperglycemic activity of leaves ofHyptis suaveolens using streptozotocin model.Methods:Hyptis suaveolensextract(HSE) 250 and 500mg/kg body weight was administered orally to streptozotocin induced diabetes, once daily for21days.Results:A significant reduction in blood glucose was observed in diabetic animals treated with HSE at different doses when compared with diabetic rats. Levels of triglyceride, total cholesterol, low density lipoprotein, very low density lipoprotein were decreased while administeringHSE at different doses, compared with their control values in diabetic animals.Conclusions: Our results show that HSEpossesses significant antihyperglycemic activity which might be attributed to stimulating effects on glucose utilization and antioxidant enzyme.