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目的:分析结外NK/T细胞淋巴瘤的临床特征、生存时间及影响预后的因素。方法:回顾性分析我院收治的结外NK/T细胞淋巴瘤33例患者的临床资料,分析临床特征、生存时间及影响预后的因素。结果:共收集结外NK/T细胞淋巴瘤患者,男女比例为2∶1,发病年龄30～50岁。Ann Arbor分期:Ⅰ期10例(30.3%),Ⅱ期5例(15.2%),Ⅲ期2例(6.06%),Ⅳ期16例(48.5%)。B组患者21例(63.6%),乳酸脱氢酶升高23例(69.7%),血β2-微球蛋白升高26例(78.8%),病变组织中EBER阳性21例(63.6%)。33例患者中死亡22例,生存11例,中位生存时间12个月,2年总生存(OS)率39.4%。单因素分析结果显示,存在B组症状、体能状况差(ZPS≥2)、LDH/血β2-微球蛋白升高、EBER阳性、临床分期≥Ⅲ期者预后差。结论:NK/T细胞淋巴瘤患者预后差,影响预后的因素包括B组症状、ZPS评分、LDH/血β2-微球蛋白水平、EBV感染、临床分期等因素。
Objective: To analyze the clinical features, survival time and prognostic factors of extranodal NK / T cell lymphoma. Methods: The clinical data of 33 patients with extranodal NK / T cell lymphoma treated in our hospital were retrospectively analyzed. The clinical characteristics, survival time and prognostic factors were analyzed. Results: A total of patients with extranodal NK / T cell lymphoma were collected. The ratio of male to female was 2: 1, and the age of onset was 30 to 50 years. Ann Arbor stage: stage Ⅰ in 10 cases (30.3%), stage Ⅱ in 5 cases (15.2%) in stage Ⅲ in 2 cases (6.06%) in stage Ⅳ in 16 cases (48.5%). There were 21 cases (63.6%) in group B, 23 cases (69.7%) in which lactate dehydrogenase was elevated, 26 cases (78.8%) were elevated in blood β2-microglobulin, and 21 cases (63.6%) were EBER positive in diseased tissues. Of the 33 patients, 22 died and 11 survived, with a median survival of 12 months and a 2-year overall survival rate of 39.4%. Univariate analysis showed that there were symptoms of B group, poor physical fitness (ZPS≥2), elevated LDH / blood β2-microglobulin, positive EBER, and poor prognosis in clinical stage Ⅲ. Conclusion: The prognosis of patients with NK / T-cell lymphoma is poor. The prognostic factors include the symptoms of B group, ZPS score, LDH / β2-microglobulin level, EBV infection, clinical stage and other factors.