论文部分内容阅读
在多种动物模型上观察了N激动剂烟碱对中枢M受体介导脑电癫痫波的影响,以研究中枢N受体对M受体功能的调节作用。急性实验以清醒脑电为指标,给两次烟碱(0.5,5.0mg/kg iV,间隔10min)促使大鼠对烟碱产生急性耐受,中枢N受体处于失敏状态下,这时M激动剂槟榔碱和毛果芸香碱诱发大鼠脑电癫痫波的阈值剂量分别由未给两次烟碱时的150mg/kg和380mg/kg降至50mg/
The effect of N-agonist nicotine on central M receptor-mediated electroencephalogram (EEG) waves was observed in a variety of animal models to investigate the central N-receptor modulatory effects on M receptor function. Acute experiments with arousal brain electricity as an indicator to two nicotine (0.5,5.0mg / kg iV, interval 10min) to promote acute nicotine in rats, central N receptors in a state of sensitivity, then M The threshold dose of the arena palmitate and pilocarpine-induced waves of electroencephalogram in rats was reduced from 150 mg / kg and 380 mg / kg without nicotine twice to 50 mg /