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鉴于目前人们高度重视遗传因素及免疫机制对病理过程和预后的影响,这种遗传因素主要指人类白细胞抗原(HLA),又称组织相容性抗原。为此作者采用微量淋巴毒试验法研究70例小儿胀发性肾小球肾炎的HLA,同时使用沉淀法检测该患者的大、中、小分子的循环免疫复合物浓度。将70例患者分为二组,第一组为肾病型,第二组为血尿型。对照组为60例同龄健康儿童。现将结果报告如下。一、研究原发型肾小球肾炎患者32个位点的HLA抗原系统,发现A_3、B_7、B_(27)、B_(35)4种抗原较健康对照组显著增高。其中肾病型主要为B_7和B_(27);血尿型主要为A_3和B_(35)。二、循环免疫复合物浓度测定发现,健康对照组主要为大分了免疫复合物;而原发性肾小球肾炎患
Given the current emphasis on genetic factors and immune mechanisms on the pathological process and prognosis, this genetic factor mainly refers to human leukocyte antigen (HLA), also known as histocompatibility antigen. For this reason, the authors used the method of microlymphatic lymphatic toxicology to study the HLA of 70 cases of infantile inflamed glomerulonephritis in children. At the same time, the concentration of circulating immune complexes of large, medium and small molecules in this patient was detected by sedimentation method. The 70 patients were divided into two groups, the first group was nephropathy, the second group was hematuria. The control group was 60 healthy children of same age. The results reported below. First, to study HLA antigen system in 32 loci of patients with primary glomerulonephritis and found that the four antigens of A_3, B_7, B_ (27) and B_ (35) were significantly higher than the healthy control group. The main types of kidney disease were B_7 and B_ (27), the hematuria types were A_3 and B_ (35). Second, the determination of circulating immune complexes concentration found that the healthy control group is mainly Oita immune complexes; and primary glomerulonephritis