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坏死性小肠结肠炎(necrotizing enterocolitis,NEC)是新生儿,尤其是胎龄32周以下或体重小于1 500 g极低出生体重儿最为常见且严重的胃肠道急症[1-2]。目前,NEC病因及其潜在发病机制尚未完全明了,NEC的早发现、早诊断、早治疗一直是临床关注的重点和难点问题。现有研究认为,围产期高危因素引起患儿局部肠道炎症,引发不恰当的瀑布式炎症级联反应,最终导致NEC的发生、发展[3]。此外,肠道黏膜上皮细胞损伤、坏死是本病特点,而
Necrotizing enterocolitis (NEC) is the most common and serious gastrointestinal emergency in neonates, especially those with gestational age less than 32 weeks or those weighing less than 1 500 g. [1-2]. At present, the etiology of NEC and its underlying pathogenesis are not fully understood. The early detection, early diagnosis and early treatment of NEC have been the focus and difficult point of clinical concern. Existing research suggests that perinatal high risk factors cause local intestinal inflammation in children, triggering inappropriate waterfall cascade reaction, eventually leading to the occurrence and development of NEC [3]. In addition, intestinal mucosal epithelial cell injury, necrosis is the characteristics of the disease, and