The synthesis and biological evaluation of a series of novel 2-COOC_2H_5/COONa substituted 1,5-benzo

• 出 处: Chinese Chemical Letters
• 发表日期: 2009年06期
• 关键词: antifungal antibacterial substituted moderate antimicrobial moiety albicans have

A series of novel 1,5-benzothiazepine derivatives containing COOC_2H_5/COONa groups at the C(2)-position were synthesized and evaluated for their antifungal and antibacterial activities by both disc diffusion and minimal inhibition concentration(MIC) methods.Most of the compounds have been shown to have moderate to good antibacterial activity against S.aureus,S.epidermidis and excellent antifungal activity against C.albicans.

A series of novel 1,5-benzothiazepine derivatives containing COOC_2H_5 / COONa groups at the C (2) -position were synthesized and evaluated for their antifungal and antibacterial activities by both disc diffusion and minimal inhibition concentration (MIC) methods. Host of the compounds have been shown to have moderate to good antibacterial activity against S. aureus, S. epidermidis and excellent antifungal activity against C. albicans.