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放疗是鼻咽癌(NPC)首选治疗手段。众所周知,病理类型、临床分期、患者年龄、体质等是影响NPC预后的主要因素,但在日常的临床工作中也不难发现,前述情况基本相似的不同患者,其治疗效果却有较大差异,从而提示还有其他重要的影响预后的因素。随着基因组学研究进展,近年来一些学者从细胞水平对基因与恶性肿瘤放射敏感性的关系进行了初步探索,但NPC组织中基因表达与放射敏感性及放疗疗效的关系如何尚不清楚,因此,有必要进一步研究以指导临床放疗。
Radiotherapy is the preferred treatment of nasopharyngeal carcinoma (NPC). As we all know, the pathological type, clinical stage, patient’s age and physique are the main factors that influence the prognosis of NPC. However, it is not difficult to find out in the routine clinical work. The treatment effect is quite different in different patients with similar similarities, Suggesting that there are other important factors that affect the prognosis. With the development of genomics, in recent years, some scholars have initially explored the relationship between gene and radiosensitivity of malignant tumors at the cellular level. However, it is unclear whether the relationship between gene expression and radiosensitivity and radiotherapy efficacy in NPC tissues is significant , It is necessary to further study to guide clinical radiotherapy.