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目的：探讨血清白细胞介素－６ （ＩＬ－６） 和透明质酸（ＨＡ）评价丹参注射液治疗慢性肝炎的临床价值。方法：采用双抗体夹心ＥＬＩＳＡ法和放射免疫分析法（ＲＩＡ），分别检测２０ 例健康献血员及３２ 例慢性病毒性肝炎（中度）患者血清ＩＬ－６、ＨＡ水平，随机将患者分为两组，分别给予丹参注射液或葡萄糖治疗４ 周后复查，观察血清ＩＬ－６、ＨＡ水平及其与ＡＬＴ、ＴＢＩＬ的关系、和丹参治疗前后上述指标的变化。结果：慢性肝炎患者血清ＩＬ－６ 和ＨＡ明显高于正常组，其水平与ＡＬＴ及ＴＢＩＬ呈显著正相关（Ｐ均＜ ０．０１）；丹参注射液治疗慢性肝炎，在降低ＡＬＴ（Ｐ＜０．０１）的同时，可明显降低血清ＩＬ－６ 和ＨＡ（Ｐ均＜ ０．０５）。结论：血清ＩＬ－６ 和ＨＡ可作为肝细胞损伤的检测指标，可用于丹参治疗慢性肝炎的评价，同时本文提示丹参治疗在保护肝细胞、抗纤维化的同时，可能具有一定的免疫调节作用。
Objective: To investigate the clinical value of serum interleukin-6 (IL-6) and hyaluronic acid (HA) in the evaluation of Danshen injection in the treatment of chronic hepatitis. Methods: Serum levels of IL-6 and HA in 20 healthy blood donors and 32 patients with chronic viral hepatitis (moderate) were measured by double antibody sandwich ELISA and radioimmunoassay (RIA). The patients were randomly divided into two groups , Were given Salvia injection or glucose treatment for 4 weeks after the review, observation of serum IL-6, HA levels and its relationship with ALT, TBIL, and Salvia before and after treatment of the above indicators. Results: The levels of serum IL-6 and HA in patients with chronic hepatitis were significantly higher than those in normal controls (P <0.01), while the levels of ALT and TBIL in patients with chronic hepatitis were significantly (P <0.01) .01) at the same time, can significantly reduce serum IL-6 and HA (P <0.05). Conclusion: Serum IL-6 and HA can be used as indicators of liver cell injury, which can be used for the evaluation of Salvia miltiorrhiza in the treatment of chronic hepatitis. Meanwhile, this study suggests that Salvia miltiorrhiza can protect liver cells and prevent fibrosis, and may have certain immunomodulatory effects.