12例贲门癌术前单次腹腔动脉灌注化疗的临床分析

• 作 者: 沈国鑫 徐友平 巴火明 张坚 茅建忠
• 机 构: 解放军第九八医院,解放军第九八医院,解放军第九八医院,解放军第九八医院,解放军第九八医院
• 出 处: 实用癌症杂志
• 发表日期: 1993年01期
• 关键词: 贲门癌 腹腔动脉灌注 核分裂 联合用药方案 空泡变性 核固缩 临床分析 胃左动脉 膈下动脉 腹主动脉旁

采用5-Fu、DDP、MMC和5-Fu、MMC、ADR两种联合用药方案对12例贲门癌进行术前单次腹腔动脉灌注化疗。对照组9例,为单纯手术者。12例患者近期临床症状均有改善,手术切除率高。肿瘤有不同程度的缩小。组织学观察空泡变性明显,核分裂频数减少,核固缩增多,与对照组比较,有非常显著差异(P<0.01)。结果表明术前单次腹腔动脉灌注化疗安全有效,还可为部分晚期贲门癌患者提供二期手术的机会。

The combination of 5-Fu, DDP, MMC, and 5-Fu, MMC, and ADR was used to perform single intra-abdominal arterial infusion chemotherapy in 12 cases of cardiac cancer. The control group consisted of 9 patients who were operated alone. In 12 patients, the recent clinical symptoms improved and the resection rate was high. The tumor shrinks to varying degrees. Histological observation revealed significant vacuolar degeneration, decreased frequency of nuclear fission, and increased nuclear pyknosis, which was significantly different from the control group (P<0.01). The results showed that single intra-abdominal arterial infusion chemotherapy before surgery is safe and effective, and it can provide second-stage surgery for some patients with advanced cardiac cancer.