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目的研究一氧化二氮清醒镇静用于内镜超声检查的安全性和有效性。方法以2015-07-01至2015-09-01于中国医科大学附属盛京医院进行内镜超声检查的762例受检者为研究对象,分为一氧化二氮吸入组(观察组,224例),常规检查组(对照组,538例),记录检查过程中患者的血压、心率、血氧饱和度、操作时间、检查后恢复时间及不良反应发生情况,进行统计学分析。结果观察组与对照组均顺利完成内镜超声检查,未出现呼吸抑制、严重心率失常等危及生命的并发症。检查前两组在血压、心率、血氧饱和度等方面差异无统计学意义,检查过程中,观察组的血压、心率显著低于对照组(P均<0.05),而在血氧饱和度方面差异无统计学意义(P>0.05)。观察组在操作时间、检查后恢复时间及不良反应上明显优于对照组(P均<0.05)。结论综合各项指标,一氧化二氮清醒麻醉对于内镜超声检查更有优势,方便易行,不良反应少,安全性高。
Objective To investigate the safety and effectiveness of conscious sedation of nitrous oxide for endoscopic ultrasonography. Methods A total of 762 subjects undergoing endoscopic ultrasonography at Shengjing Hospital of China Medical University from July 2015 to January 2015 were enrolled and divided into two groups: nitrous oxide inhalation group (observation group, 224 cases ), Routine examination group (control group, 538 cases). The blood pressure, heart rate, blood oxygen saturation, operation time, recovery time after the examination and the incidence of adverse reactions were recorded and analyzed statistically. Results The observation group and the control group were successfully completed endoscopic ultrasonography, no respiratory complications, serious heart rate disorders and other life-threatening complications. There was no significant difference in blood pressure, heart rate and oxygen saturation between the two groups before examination. During the examination, the blood pressure and heart rate in the observation group were significantly lower than those in the control group (P <0.05) The difference was not statistically significant (P> 0.05). The observation group was significantly better than the control group in operation time, recovery time and adverse reactions after the examination (all P <0.05). Conclusion Based on the various indexes, NOS anesthesia has more advantages for endoscopic ultrasonography, which is convenient and easy to operate with less adverse reactions and high safety.