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维生素A、C、E都有一定的防癌变作用,特别是防止化学致癌的作用。对于维生素K类,国外也已经开展了许多研究工作,结果表明,它具有抗肿瘤活性、抗致癌作用,以及与抗代谢药配伍产生协同作用。维生素K类(以下简称维K类)系一组2-甲基-1,4-萘醌的衍生物,包括维K_1、K_2和K_3,其分子中均带有产生脂溶性的平面萘环和易接受电子的醌基结构。本文就近年来维K类的抑瘤活性、作用机理及抗致癌作用诸方面作一简要综述。一、维K类的抑瘤活性 Mitchell等首先报道维K类化合物对肿瘤具有抑制效果。Bernacki等证实维K_1能选择性地抑制体外培养的小鼠白
Vitamin A, C, E have a certain anti-cancer effect, especially to prevent the role of chemical carcinogens. For vitamin K class, a lot of research work has been carried out abroad, the results show that it has anti-tumor activity, anti-carcinogenic effects, and compatibility with anti-metabolite synergy. Vitamin K (hereinafter referred to as dimension K) is a group of derivatives of 2-methyl-1,4-naphthoquinone, including vitamin K_1, K_2 and K_3, both of which have a fat-soluble planar naphthalene ring and Easy to accept electronic quinone-based structure. This article in recent years, Victoria K class antitumor activity, mechanism of action and anti-carcinogenic aspects of a brief review. First, the dimensional K-type anti-tumor activity Mitchell other reports first dimension K compounds have inhibitory effect on the tumor. Bernacki et al confirmed that vitamin K_1 can selectively inhibit mouse white culture in vitro