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为了对我室研制的幼儿用气动隔膜泵今后的临床应用提供依据,进行了离体和在体两方面的评价。模拟实验表明,影响泵输出量的主要因素是驱动正压和频率,而驱动负压作用相对较小。在驱动正压150～220mmHg间,泵输出量随正压加大而提高;在一定的驱动频率范围内和驱动正压下,泵输出量随频率增加而提高;仅就驱动负压而言,在-40～-60mmHg间.泵输出量最大且无明显变化,因此较为合适的驱动负压是-40mmHg。动物实验结果显示,当心衰犬的主动脉平均压在65mmHg以下时,驱动正压仅150mmHg、负压-40mmHg、频率75bpm条件下,即可达到90％的辅助流率,这就提示在今后的临床应用中,无需采取过高的驱动正压。动物实验证明泵最大每搏量为15.5ml,达到了每搏量15ml的设计要求,如驱动频率在60bpm以上,可达900ml左右的辅助流量,因而能满足15公斤以下体重幼儿患者心脏辅助的需要。
In order to provide a basis for future clinical application of pneumatic diaphragm pump for infants developed in our hospital, both in vitro and in vivo evaluation were carried out. Simulation experiments show that the main factors that affect the pump output are driving positive pressure and frequency, while the driving negative pressure is relatively small. In the driving positive pressure 150 ~ 220mmHg, the pump output increases with the positive pressure increases; within a certain range of driving frequency and driving positive pressure, the pump output increases with increasing frequency; only to drive the negative pressure, In -40 ~ -60mmHg between the pump output maximum and no significant change, so a more appropriate negative pressure is -40mmHg. Animal experiments show that when the aortic heart failure average heart rate of 65mmHg below the driving positive pressure is only 150mmHg, negative pressure -40mmHg, frequency 75bpm conditions, you can reach 90% of the auxiliary flow rate, which suggests that in the future The clinical application, without taking too much pressure to drive positive. Animal experiments show that the pump maximum stroke volume of 15.5ml, stroke volume 15ml reached the design requirements, such as the driving frequency of 60bpm above, up to about 900ml auxiliary flow, which can meet the weight of children under 15 kg of cardiac assist needs .