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对哮喘儿童发作期３１例，缓解期４４例进行了Ｔ淋巴细胞亚群和白细胞介素－２细胞膜表达阳性细胞（ｍＩＬ－２Ｒ）的检测，并与正常儿童３０例进行对比。结果哮喘发作期ＣＤ４、ＣＤ４／ＣＤ８、ｍＩＬ２Ｒ增高，ＣＤ８下降（皆Ｐ＜００１）。哮喘缓解期ＣＤ８下降，ＣＤ４／ＣＤ８增高（皆Ｐ＜００５）。发作期和缓解期比较ＣＤ４和ｍＩＬ２Ｒ均增高（Ｐ＜００１）表明儿童哮喘缓解期即存在有ＣＤ８的降低和ＣＤ４／ＣＤ８的增高，一旦受内外致喘因子刺激，可使ＣＤ４细胞活化，表现为其本身及其活化的主要标志之一，ｍＩＬ２Ｒ的增高，活化的ＣＤ４细胞释放一系例生物活性物质，从而导致哮喘的急性发作。
Thirty-one cases of asthmatic children onset and 44 cases of remission were detected by T lymphocyte subpopulation and interleukin-2 cell membrane-positive cells (mIL-2R), compared with 30 normal children. Results The number of CD4, CD4 / CD8 and mIL2R in asthma attack increased and CD8 decreased (all P <001). CD8 decreased and CD4 / CD8 increased during asthma remission (all P <005). Compared with the control group, the CD4 and mIL2R levels were significantly increased in the attack and remission stages (P <001), indicating that there was a decrease of CD8 and CD4 / CD8 in the remission stage of asthma in children. Once stimulated by both internal and external asthma, Activated, manifested itself and its activation of one of the main signs of increased mIL 2R, activated CD4 cells release a number of bioactive substances, resulting in an acute attack of asthma.